Anti-TSHR Reference Antibody (K1-70)
Recombinant Antibody
- SPECIFICATION
 - CITATIONS
 - PROTOCOLS
 - BACKGROUND
 
Application 
  | FC, Kinetics, Animal Model | 
|---|---|
| Primary Accession | P16473 | 
| Reactivity | Human | 
| Clonality | Monoclonal | 
| Isotype | IgG1 | 
| Calculated MW | 143.54 KDa | 
| Target/Specificity | TSHR | 
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. | 
| Conjugation | Unconjugated | 
| Expression system | CHO Cell | 
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. | 
| Name | TSHR | 
|---|---|
| Synonyms | LGR3 | 
| Function | Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity). | 
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein | 
| Tissue Location | Expressed in thyroide cells (at protein level) (PubMed:11847099). Expressed in the thyroid (PubMed:2610690) | 

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