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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-TNFRSF10A / TRAILR1 / CD261 Reference Antibody ( mapatumumab)
Anti-TNFRSF10A / TRAILR1 / CD261 Reference Antibody ( mapatumumab)
Recombinant Antibody
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- BACKGROUND
Application 
| FC, E, FTA |
|---|---|
| Primary Accession | O00220 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | IgG2SA |
| Calculated MW | 145 KDa |
| Target/Specificity | TNFRSF10A / TRAILR1 / CD261 |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Storage | -80°C for 2 years under sterile conditions； -20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles. |
| Name | TNFRSF10A |
|---|---|
| Synonyms | APO2, DR4, TRAILR1 |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF- kappa-B (PubMed:9430227). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Membrane raft. Cytoplasm, cytosol. Note=Palmitoylation is required for association with membranes. |
| Tissue Location | Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K- 562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 365.00
Cat# APR10535
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