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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-Adrenomedullin Reference Antibody (enibarcimab)
Anti-Adrenomedullin Reference Antibody (enibarcimab)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, Kinetics, Animal Model |
|---|---|
| Primary Accession | P35318 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 145.82 KDa |
| Target/Specificity | Adrenomedullin |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Name | ADM (HGNC:259) |
|---|---|
| Synonyms | AM |
| Function | Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:8387282, PubMed:9620797). Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. |
| Cellular Location | Secreted. |
| Tissue Location | Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# APR10539
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