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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-CD48 Reference Antibody (Regeneron patent anti-CD48)
Anti-CD48 Reference Antibody (Regeneron patent anti-CD48)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, E, FTA |
|---|---|
| Primary Accession | P09326 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | IgG4sp |
| Calculated MW | 150 KDa |
| Target/Specificity | CD48 |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Storage | -80°C for 2 years under sterile conditions； -20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles. |
| Name | CD48 |
|---|---|
| Synonyms | BCM1, BLAST1 |
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:27249817, PubMed:12007789). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex (PubMed:19494291). In turn, promotes LCK phosphorylation and subsequent activation (PubMed:12007789). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T- lymphocytes and NK-cells (PubMed:9841922, PubMed:27249817). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted |
| Tissue Location | Widely expressed on all hematopoietic cells. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 365.00
Cat# APR10809
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