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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-SCN11a / Nav1.9 Reference Antibody (Wuhan U. patent anti-Nav1.9)
Anti-SCN11a / Nav1.9 Reference Antibody (Wuhan U. patent anti-Nav1.9)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, E, FTA |
|---|---|
| Primary Accession | Q9UI33 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 143.94 KDa |
| Target/Specificity | SCN11a / Nav1.9 |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Storage | -80°C for 2 years under sterile conditions； -20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles. |
| Name | SCN11A (HGNC:10583) |
|---|---|
| Function | Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient (PubMed:10580103, PubMed:12384689, PubMed:24036948, PubMed:24776970, PubMed:26645915, PubMed:25791876). Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system (PubMed:24036948, PubMed:24776970, PubMed:26645915, PubMed:25791876). Also involved in rapid BDNF-evoked neuronal depolarization (PubMed:12384689). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. |
Research Areas
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Application Protocols
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$ 365.00
Cat# APR11028
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