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DRAK1 Antibody

     
  • WB - DRAK1 Antibody ASC10072
    Western blot analysis of DRAK1 in (A) MOLT4 and (B) A431 whole cell lysates with DRAK1 antibody at 1 µg/mL.
    detail
  • ICC - DRAK1 Antibody ASC10072
    Immunocytochemistry staining of MOLT4 cells using DRAK1 antibody at 2 µg/mL.
    detail
  • IF - DRAK1 Antibody ASC10072
    Immunofluorescence of DRAK1 in Molt cells with DRAK1 antibody at 20 µg/mL.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, ICC, E
Primary Accession Q9UEE5
Other Accession Q9UEE5, 14423930
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 50 kDa
Application Notes DRAK1 antibody can be used for detection of DRAK1 by Western blot at 1 µg/mL. An approximately 50 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 2 µg/mL. For immunofluorescence start at 10 µg/mL.
Additional Information
Gene ID 9263
Other Names DRAK1 Antibody: DRAK1, DRAK1, DAP kinase-related apoptosis-inducing protein kinase 1, serine/threonine kinase 17a
Target/Specificity STK17A; No cross responses to DRAK2, DAP or ZIP kinases.
Reconstitution & Storage DRAK1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsDRAK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STK17A
Synonyms DRAK1
Function Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.
Cellular Location Nucleus.
Tissue Location Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas
Research Areas
Citations (0)
citation

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Background

DRAK1 Antibody: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.

References

Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem 1998;273:29066-71


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$ 379.00
Cat# ASC10072
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