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VENTX Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | O95231 |
| Other Accession | NP_055283, 7657180 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 27552 Da |
| Application Notes | VENTX antibody can be used for detection of VENTX by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. |
| Gene ID | 27287 |
|---|---|
| Target/Specificity | VENTX; |
| Reconstitution & Storage | VENTX antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | VENTX Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VENTX |
|---|---|
| Synonyms | HPX42B, VENTX2 |
| Function | May be involved in ventralization. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
VENTX Antibody: Lymphoid-enhancing factor/T-cell factors (LEF1/TCF) are a high-mobility group of transcriptional factors that play essential roles in cell fate determination during early embryogenesis and ontogenesis. VENTX is a member of the Vent family of homeodomain proteins. It is a novel LEF/TCF-associated transcriptional modulator. VENTX is predominately expressed in hematopoietic cells. VENTX may function as a transcriptional repressor and be involved in mesodermal patterning and hemapoietic stem cell maintenance, and has been suggested to have a potential role in the hematopoietic malignancies.
References
Reya T and Clevers H. Wnt signalling in stem cells and cancer. Nature2005; 434:843-50.
Moretti PA, Davidson AJ, Baker E, et al. Molecular cloning of a human Vent-like homeobox gene. Genomics2001; 76:21-9.
Gao H, Le Y, Wu X, et al. VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor. Cancer Res.2010; 70:202-11.
Shtutman M, Zhurinsky J, Simcha I, et al. The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. USA1999; 96:5522-7.
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