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TEKT5 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96M29 |
| Other Accession | NP_653275, 21389569 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 56294 Da |
| Application Notes | TEKT5 antibody can be used for detection of TEKT5 by Western blot at 0.5 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. |
| Gene ID | 146279 |
|---|---|
| Target/Specificity | TEKT5; This antibody is predicted to not cross-react with other Tektin protein family members |
| Reconstitution & Storage | TEKT5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | TEKT5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TEKT5 |
|---|---|
| Function | Sperm-specific microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellar axoneme. Forms an extensive interaction network in different conformations that reinforces the helix bundle composed by other tektin proteins (TEKT1 to TEKT4) and MIPs to anchor the tektin bundle onto the tubulin wall of A- tubule of the sperm flagellum. |
| Cellular Location | Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:G5E8A8} |
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Provided below are standard protocols that you may find useful for product applications.
Background
TEKT5 Antibody: Tektins are insoluble alpha-helical proteins related to intermediate filament proteins and are essential for the assembly of cilia and flagella. Tektin-5 (TEKT5) is a recently identified member of the Tektin family. It is predominantly expressed in testis, and its expression is upregulated during testis development. It is present in sperm flagella but not in heads, suggesting that it may act as a middle component required for flagellar stability and sperm mobility.
References
Amos LA. The tektin family of microtubule-stabilizing proteins. Genome Biol. 2008; 9:229.
Murayama E, Yamamoto E, Kaneko T, et al. Tektin5, a new Tektin family member, is a component of the middle piece of flagella in rat spermatozoa. Mol. Reprod. Dev. 2008; 75:650-8.
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