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STOX1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6ZVD7 |
| Other Accession | NP_689922, 63025200 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 110962 Da |
| Application Notes | STOX1 antibody can be used for detection of STOX1 by Western blot at 1 µg/mL. |
| Gene ID | 219736 |
|---|---|
| Target/Specificity | STOX1; STOX1 antibody is human reactive. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. STOX1 antibody recognize the two longest isoforms. |
| Reconstitution & Storage | STOX1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | STOX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STOX1 |
|---|---|
| Synonyms | C10orf24 |
| Function | Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity). |
| Cellular Location | [Isoform A]: Cytoplasm. Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In epithelial cells, diffusely expressed in the cytoplasm, particularly in peri-membrane cortical regions (By similarity). Concentrated at centrosomes during metaphase (PubMed:22253775). {ECO:0000250|UniProtKB:B2RQL2, ECO:0000269|PubMed:22253775} [Isoform C]: Nucleus, nucleolus. |
| Tissue Location | Expressed in placenta, including the invasive extravillus trophoblast cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
STOX1 Antibody: STOX1 (Storkhead box 1), also known as PEE4 or C10orf24, is a winged-helix domain containing transcription factor believed to play a role in the differentiation of stem cells. As a DNA-binding protein, STOX1 exists as three alternatively spliced isoforms, designated A, B and C, all of which localize to either the cytoplasm or the nucleus. Defects in STOX1 are the cause of pre-eclampsia/eclampsia 4 (PEE4), also known as gestational proteinuric hypertension. STOX1 was also found to be functionally involved in late-onset Alzheimer's disease.
References
Van Dijk M, van Bezu J, Chim SS, et al. Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. Nat. Genet. 2005; 37:514-9.
Kivinen K, Peterson H, Hiltunen L, et al. Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample. Eur. J. Hum. Genet. 2007;15:494-7.
Van Dijk M, van Bezu J, van Abel D, et al. The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation. Hum Mol. Genet. 2010; 19:2658-67.
Van Abel D, Hölzel DR, Jain S, et al. SFRS7-mediated splicing of tau exon 10 is directly regulated by STOX1A in glial cells. PLoS One 2011; 6 :e21994.
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