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SEPT1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, ICC, E |
|---|---|
| Primary Accession | Q8WYJ6 |
| Other Accession | NP_443070, 431822382 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 42386 Da |
| Application Notes | SEPT1 antibody can be used for detection of SEPT1 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 5 µg/mL. For immunofluorescence start at 5 µg/mL. |
| Gene ID | 1731 |
|---|---|
| Target/Specificity | SEPT1; At least two isoforms of SEPT1 are known to exist. This antibody is predicted to not cross-react with other Septin protein family members. |
| Reconstitution & Storage | SEPT1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | SEPT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SEPTIN1 (HGNC:2879) |
|---|---|
| Synonyms | DIFF6, PNUTL3, SEPT1 |
| Function | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis |
| Tissue Location | Expressed at high levels in lymphoid and hematopoietic tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SEPT1 Antibody: SEPT1 (also known as Septin 1), is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. SEPT1 was initially identified through yeast two-hybrid screening as an interaction partner for the serine/threonine kinase Aurora-B. During mitosis, SEPT1 localizes to the spindle pole, suggesting that it may play a role in cytokinesis and chromosome congression.
References
Qi M, Yu W, Liu S, et al. Septin1, a new interaction partner for human serine/threonine kinase aurora-B. Biochem. Biophys. Res. Commun. 2005; 336:994-1000.
Russell SE and Hall PA. Septin genomics: a road less travelled. Biol. Chem. 2011; 392:763-7.
Zhu J, Qi ST, Wang YP, et al. Septin1 is required for spindle assembly and chromosome congression in mouse oocytes. Dev. Dyn. 2011; 240:2281-9.
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