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IL-9 Antibody

     
  • WB - IL-9 Antibody  ASC11705
    Western blot analysis of IL-9 in human spleen tissue lysate at 1 µg/ml.
    detail
  • IHC - IL-9 Antibody  ASC11705
    Immunohistochemistry of IL-9 in human spleen tissue with IL-9 antibody at 5 µg/mL.
    detail
  • IF - IL-9 Antibody  ASC11705
    Immunofluorescence of IL-9 in human spleen tissue with IL-9 antibody at 20 µg/mL.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P15248
Other Accession NP_000581, 10834980
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 13 kDa

Observed: 22kDa
Application Notes IL-9 antibody can be used for detection of IL-9 by Western blot at 1 - 2 µg/ml.
Additional Information
Gene ID 3578
Target/Specificity IL9; IL-9 antibody is human specific. IL-9 antibody is predicted to no cross-react with IL-7.
Reconstitution & Storage IL-9 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsIL-9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL9
Function Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:29742432). Affects intestinal epithelial permeability and adaptive immunity (PubMed:29742432). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5.
Cellular Location Secreted.
Research Areas
Citations (0)
citation

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Background

Interleukin 9 (IL-9) is a cytokine secreted by TH2 lymphocytes that acts as a regulator of a variety of hematopoietic cells, stimulates cell proliferation and prevents apoptosis (1,2). It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins (3). The IL-9 gene has been identified as a candidate gene for asthma (4). Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness (5).

References

Renauld JC, Goethals A, Houssiau F, et al. Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40. Cytokine 1990; 2:9-12.
Tete S, Saggini A, Maccauro G, et al. Interleukin-9 and mast cells. J. Biol. Homeost. Agents 2012; 26:319-26.
Knoops L and Renauld JC. IL-9 and its receptor: from signal transduction to tumorigenesis. Growth Factors 2004; 22:207-15.
Nicolaides NC, Holroyd KJ, Ewart SL, et al. Interleukin 9: a candidate gene for asthma. Proc. Natl. Acad. Sci. USA 1997; 94:13175-80.

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$ 379.00
Cat# ASC11705
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