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DNAJA4 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WW22 |
| Other Accession | NP_061072, 194328758 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 41, 44, 47 kDa Observed: 40 kDa |
| Application Notes | DNAJA4 antibody can be used for detection of DNAJA4 by Western blot at 1 - 2 µg/ml. |
| Gene ID | 55466 |
|---|---|
| Target/Specificity | DNAJA4; DNAJA4 antibody is human, mouse, and rat reactive. At least three isoforms of DNAJA4 are known to exist; this antibody will detect all three isoforms. |
| Reconstitution & Storage | DNAJA4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | DNAJA4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DNAJA4 |
|---|---|
| Cellular Location | Membrane; Lipid-anchor |
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Provided below are standard protocols that you may find useful for product applications.
Background
The DNAJA4 protein is the mammalian homolog of the chaperone HSP40 (1) and acts as a co-chaperone with the heat shock protein HSP70 (2). DNAJA4 is highly expressed in heart and testis, accounting for approximately 1% of total protein in mouse heart (2). DNAJA4 is also regulated by the sterol regulatory element binding transcription factor 2 (SREBF2) and plays a role in the synthesis of cholesterol (3).
References
Ohtsuka K and Hata M. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Cell Stress Chaperones 2000; 5:98-112.
Abdul KM, Terada K, Gotoh T, et al. Characterization and functional analysis of a heart-enriched DnaJ / Hsp40 homolog dj4/DjA4. Cell Stress Chaperones 2002; 7:156-66.
Robichon C, Varret M, Le Liepvre X, et al. DnajA4 is a SREBP-regulated chaperone involved in the cholesterol biosynthesis pathway. Biochim. Biophys. Acta 2006; 1761:1107-13.
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