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NDST1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P52848 |
| Other Accession | NP_001534 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone Names | NDST1 |
| Calculated MW | Predicted: 97 kDa Observed: 97 kDa |
| Gene ID | 15531 |
|---|---|
| Alias Symbol | NDST1 |
| Other Names | NDST1 Antibody: HSST, NST1, MRT46 |
| Target/Specificity | NDST1 Antibody is predicted to not cross-react with NDST2. |
| Reconstitution & Storage | NDST1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | NDST1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NDST1 (HGNC:7680) |
|---|---|
| Synonyms | HSST, HSST1 |
| Function | [Isoform 1]: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:9230113, PubMed:9744796, PubMed:35137078). Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:9230113). Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). |
| Cellular Location | [Isoform 1]: Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type II membrane protein |
| Tissue Location | Widely expressed. Expression is most abundant in heart, liver and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NDST1 is a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. It is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate.
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