CD28 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, IF, E |
---|---|
Primary Accession | P10747 |
Other Accession | P10747 |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Clone Names | CD28 |
Calculated MW | Predicted: 28 kDa Observed: 26 kDa |
Gene ID | 940 |
---|---|
Alias Symbol | CD28 |
Other Names | CD28 Antibody: CD28 Molecule, CD28 Antigen, Tp44, T-Cell-Specific Surface Glycoprotein CD28, T-Cell-Specific Surface Glycoprotein, CD28 Antigen (Tp44) |
Reconstitution & Storage | CD28 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Precautions | CD28 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD28 |
---|---|
Function | Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). |
Cellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Location | Expressed in T-cells and plasma cells, but not in less mature B-cells |
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