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SIGLEC15 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6ZMC9 |
| Other Accession | NP_998767 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone Names | SIGLEC15 |
| Calculated MW | Predicted: 36kD Observed: 34-36kD |
| Gene ID | 284266 |
|---|---|
| Alias Symbol | SIGLEC15 |
| Other Names | SIGLEC15 Antibody: CD33L3, HsT1361, SIGLEC-15, CD33L3, Sialic acid-binding Ig-like lectin 15, CD33 antigen-like 3, Siglec-15 |
| Reconstitution & Storage | SIGLEC15 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | SIGLEC15 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SIGLEC15 |
|---|---|
| Synonyms | CD33L3 |
| Function | Binds sialylated glycoproteins. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Expressed in macrophage and/or dendritic cells of spleen and lymph nodes |
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Provided below are standard protocols that you may find useful for product applications.
Background
SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.
References
Crocker and Redelinghuys. Biochem. Soc. Trans. 2008; 36:1467-71.Angata et al. Glycobiology 2007; 17:838-46.Hiruma et al. Biochem. Biophys. Res. Commun. 2011; 409:424-9.
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