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TMEM41B (CT) Antibody
Infectious Disease, COVID-19
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q5BJD5 |
| Other Accession | Q5BJD5 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone Names | TMEM41B |
| Calculated MW | Predicted: 33kD Observed: 33 kD |
| Application Notes | WB: 2 μg/mL; IF: 20 μg/mL. Antibody validated: Western Blot in mouse and rat samples; Immunofluorescence in human, mouse and rat samples. All other applications and species not yet tested. |
| Gene ID | 440026 |
|---|---|
| Alias Symbol | TMEM41B |
| Other Names | TMEM41B Antibody: Transmembrane protein 41B, Protein stasimon, TMEM41B, KIAA0033. |
| Reconstitution & Storage | TMEM41B antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | TMEM41B (CT) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMEM41B {ECO:0000303|PubMed:30352685, ECO:0000312|HGNC:HGNC:28948} |
|---|---|
| Function | Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (PubMed:34015269, PubMed:33929485, PubMed:33850023). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (PubMed:34015269, PubMed:33929485, PubMed:33850023). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:30093494, PubMed:30126924, PubMed:30933966, PubMed:34015269, PubMed:33929485, PubMed:34043740, PubMed:33850023). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:33850023). Required for normal motor neuron development (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Endomembrane system Note=Localized to specific membrane structures termed mitochondria- associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TMEM41B Antibody: TMEM41B is required for autophagosome formation and participates in early stages of autophagosome biogenesis at the ER membrane probably via mobilization of neutral lipids from lipid droplets. TMRM41B is a critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus. It is required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles.
References
Moretti et al. EMBO Rep. 2018; 19(9):e45889.
Shoemaker et al. PLoS Biol. 2019; 17(4):e2007044.
Schneider et al. Cell 2021; 184(1):120-132.
Hoffmann et al. Cell 2021; 184(1):133-148.e20.
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