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PP5 Antibody
PP5 Antibody, Clone 2E11
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | P53041 |
| Other Accession | NP_006238.1 |
| Host | Mouse |
| Isotype | IgG2a |
| Reactivity | Human |
| Clonality | Monoclonal |
| Description | Mouse Anti-Human PP5 Monoclonal IgG2a |
| Target/Specificity | Detects ~58kDa. |
| Other Names | PPP5 Antibody, PPT Antibody, Protein phosphatase T Antibody, Serine/threonine protein phosphatase 5 Antibody |
| Clone Names | 2E11 |
| Immunogen | Full length human PP5 protein |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-243 was sufficient for detection of PP5 in 15 µg of human A431 lysates by ECL analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Nucleus | Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues, potentially playing a role in the regulation of cell growth and differentiation. PP5 or PPT is predominantly a nuclear protein and interacts with CDC16 and CDC27. It is found in association with several proteins that influence intracellular signlaing-cascades intitiated by hormones (glucocorticoids) or cellular stress (hypoxia, oxidative stress and DNA Damage). It phosphorylates serine residues of skeletal muscle phosphorylase and histone H1. It may also be involved in mitosis and RNA biogenesis regulation (1,2).
References
1. Butzow R., et al. (1988) J Lab Clin Med. 111(2): 249-256.
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