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VDAC1 Antibody
VDAC1 Antibody, Clone S152B-23
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- BACKGROUND
Application 
| WB, IHC, ICC |
|---|---|
| Primary Accession | P21796 |
| Other Accession | NP_003365.1. |
| Host | Mouse |
| Isotype | IgG2a |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Human VDAC1 Monoclonal IgG2a |
| Target/Specificity | Detects ~30kDa. Does not cross-react with VDAC2 or VDAC3 (based on KO validation results). |
| Other Names | Voltage Dependent Anion Channel 1 Antibody, Porin Antibody, Voltage dependent anion selective channel protein 1 Antibody, Voltage-dependent anion-selective channel protein 1 Antibody, hVDAC1 Antibody, MGC111064 Antibody, Mitochondrial Porin Antibody, Outer mitochondrial membrane protein porin 1 Antibody, Plasmalemmal porin Antibody, Porin 31HL Antibody, Porin 31HM Antibody, PORIN-31-HL Antibody, VDAC 1 Antibody, VDAC Antibody, VDAC-1 Antibody |
| Clone Names | S152B-23 |
| Immunogen | Fusion protein amino acids 1-283 (full-length) of human VDAC1. Mouse: 98% identity (279/283 amino acids identical). Rat: 98% identity (279/283 amino acids identical) >60% identity with VDAC2 and VDAC3. |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH 7.4, 50% glycerol, 0.1% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-456 was sufficient for detection of VDAC1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Mitochondrion | Mitochondrion Outer Membrane | Cell Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
Voltage-dependent anion-selective channel protein 1 (also known as VDAC, VDAC1 or outer mitochondrial membrane protein porin 1) is the the outer mitochondrial membrane receptor for hexokinase and BCL2L1. VDAC forms a channel through the mitochondrial membrane and is involved in small molecule diffusion, cell volume regulation and apoptosis. VDAC may participate in the formation of the permeability transition pore complex (PTPC), which is responsible for the release of mitochondrial products that triggers apoptosis.
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