|Application ||WB, ICC/IF|
|Description||Rabbit Anti-Human Beclin 1 Polyclonal|
|Target/Specificity||Predicted molecular weight at ~51kDa. Observed a secondary band on some lysates at ~30kDa.|
|Other Names||APG6 Antibody, BCL-2 interacting protein beclin Antibody, Beclin 1 autophagy related Antibody, BECN1 Antibody, BECN1_HUMAN Antibody, GT197 Antibody, VPS30 Antibody|
|Immunogen||Synthetic peptide from the mid-protein of human Beclin 1|
|Purification||Peptide Affinity Purified|
|Storage Buffer||PBS, 50% glycerol, 0.09% sodium azide|
|Shipping Temperature||Blue Ice or 4ºC|
|Certificate of Analysis||A 1:1000 dilution of SPC-600 was sufficient for detection of Beclin1 on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.|
|Cellular Localization||Cytoplasm | Golgi apparatus | Trans-Golgi network membrane| Endosome | Endoplasmic reticulum membrane | Mitochondrion | Mitochondrion membrane | Cytoplasmic vesicle | Autophagosome|
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Provided below are standard protocols that you may find useful for product applications.
Beclin 1 is the mammalian ortholog of the yeast autophagy -related gene Atg6. It regulates autophagy and has an important role in development, tumorigenesis and neurodegeneration (1). Beclin 1 is localized within cytoplasmic structures including the mitochondria, yet overexpression reveals some nuclear staining (2). Researchers have found that schizonphrenia is associated with low levels of Beclin-1 in the hippocampus (3). It may also protect against infection by a neuorvirulent strain of Sindbis virus (4).
1. Zhong Y., et al. (2009) Nat Cell Biol. 11(4): 468-476.
2. Liang X.H., et al. (2001) Cancer Res. 61: 3443-3449.
3. Merenlender-Wagner A., et al. (2013) Mol. Psychiatry 20:126-132.
4. Liang X.H., et al. (1998) J Virol. 72: 8586-8596.
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