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ROR2 Antibody
Rabbit Anti-Human ROR2 Polyclonal
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC |
|---|---|
| Primary Accession | Q01974 |
| Other Accession | NP_001305133.1 |
| Host | Rabbit |
| Reactivity | Rat |
| Clonality | Polyclonal |
| Format | ROR2 |
| Target/Specificity | ROR2 |
| Other Names | NTRKR2 Antibody, Tyrosine-protein kinase transmembrane receptor ROR2 Antibody, receptor-related 2 Antibody, ROR2 Antibody, Neurotrophic tyrosine kinase, Receptor tyrosine kinase-like orphan receptor 2 antibody, Neurotrophic tyrosine kinase, receptor related 2 antibody |
| Clone Names | ROR2 |
| Immunogen | Synthetic peptide of Human ROR2 (100-200 aa), conjugated to Keyhole Limpet Haemocyanin (KLH). |
| Purification | Peptide Affinity Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | A 1:1000 dilution of SPC-739 was sufficient for detection of ROR2 in 10 µg of human HeLa cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody. |
| Cellular Localization | Cell Membrane | Single-Pass Type I Membrane Protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
ROR2 is a receptor tyrosine kinase which may have a role in early cartilage and growth plate development. ROR2 expression is generally highest during embryonic development and will gradually decrease as cells terminally differentiate. Wnt5a has been identified to utilize ROR2 as a co-receptor for non-canonical Wnt signalling. Aberrant expression of ROR2 has been implicated in gastric, osteosarcoma, mestatic melanoma, prostate, renal cell and squamous cell carcinomas. Increased expression of ROR2 was correlated with increased metastasis. In prostate, osteosarcomas and metastatic melanomas, Wnt5a/ROR2 receptor complex formation was implicated as the mechanism for cancer progression. ROR2 seems to function as an oncogene. Primarily mis-sense mutations of ROR2 have been identified in tumours but their functional effect has not been well characterized.
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