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Anti-OspC (RABBIT) Antibody
OspC Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Host | Rabbit |
|---|---|
| Conjugate | Unconjugated |
| Target Species | Borrelia burgdorferi |
| Clonality | Polyclonal |
Application 
| WB, I, LCI |
| Application Note | This protein-A purified antibody has been tested for use in Western blotting and in ELISA. Specific conditions for reactivity should be optimized by the user. Expect a band approximately 20.7 kDa in size corresponding to Borrelia burgdorferi OspC protein by Western blotting in the appropriate cell lysate or extract. |
| Physical State | Lyophilized |
| Buffer | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
| Immunogen | MBP-fusion protein corresponding to Borrelia burgdorferi OspC protein. |
| Reconstitution Volume | 100 µL |
| Reconstitution Buffer | Restore with deionized water (or equivalent) |
| Preservative | 0.01% (w/v) Sodium Azide |
| Other Names | 1194415 |
|---|---|
| Purity | This product was Protein-A purified and cross-adsorbed against MBP from monospecific antiserum by chromatography. This antibody is specific for Borrelia burgdorferi OspC protein. A BLAST analysis was used to suggest cross-reactivity with p39 from B. burgdorferi, afzelii, and valaisiana sources based on 100% homology with the immunizing sequence. Partial reactivity is expected against B. japonica and americana sources based on 94% homology. Cross-reactivity with OspC from other sources has not been determined. |
| Storage Condition | Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. |
| Precautions Note | This product is for research use only and is not intended for therapeutic or diagnostic applications. |
| Name | ospC {ECO:0000303|PubMed:8478108} |
|---|---|
| Function | A major immunodominant protein in mammalian hosts (PubMed:8098841, PubMed:8225587, PubMed:8478109). Required for the initial stages of mammalian infection (PubMed:14970347, PubMed:16714588, PubMed:20199597, PubMed:28873507). Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo (PubMed:18752445). Inhibits macrophage-mediated phagocytosis of the bacteria (PubMed:26438793). Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue (PubMed:20199597, PubMed:22433849). Binds human complement C4-B, which may inhibit the complement cascade (Probable) (PubMed:28873507). Experiments in mice suggest it may play another role after initial infection (Probable) (PubMed:27611840). |
| Cellular Location | Cell outer membrane; Lipid-anchor. Cell surface Note=Expressed in a punctate fashion on a subset of cells in vitro |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Outer Surface Protein C, or OspC, is a 20.7 kDa immunogenic protein on the outer surface of the spirochete Borrelia burgdorferi. Its function is not known, but it is located with lipid-anchoring sites on the outer cell membrane.
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$ 499.00
Cat# ASR4443
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