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> home > Products > Primary Antibodies > Signal Transduction > Anti-CARBOXYPEPTIDASE Y (RABBIT) Antibody Biotin Conjugated
Anti-CARBOXYPEPTIDASE Y (RABBIT) Antibody Biotin Conjugated
Carboxypeptidase Y Antibody Biotin Conjugated
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Host | Rabbit |
|---|---|
| Conjugate | Biotin |
| Target Species | Saccharomyces cerevisiae |
| Reactivity | Saccharomyces cerevisiae |
| Clonality | Polyclonal |
Application 
| WB, E, I, LCI |
| Application Note | Anti-Carboxypeptidase Y Biotin Antibody has been tested by ELISA and Western Blot and is assayed against 1.0 ug of Carboxypeptidase Y in a standard capture ELISA using Peroxidase Conjugated Streptavidin #S000-03 and ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid]) code # ABTS-100 as a substrate for 30 minutes at room temperature. A working dilution of 1:4,000 to 1:20,000 of the reconstitution concentration is suggested for this product. |
| Physical State | Lyophilized |
| Buffer | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
| Immunogen | Carboxypeptidase Y [Baker’s Yeast] |
| Reconstitution Volume | 100 µL |
| Reconstitution Buffer | Restore with deionized water (or equivalent) |
| Stabilizer | 10 mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free |
| Preservative | 0.01% (w/v) Sodium Azide |
| Gene ID | 855343 |
|---|---|
| Other Names | 855343 |
| Purity | Anti-Carboxypeptidase Y is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Biotin, anti-Rabbit Serum as well as purified and partially purified Carboxypeptidase Y [Baker’s Yeast]. Cross reactivity against Carboxypeptidase Y from other sources may occur but has not been specifically determined. |
| Storage Condition | Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. |
| Precautions Note | This product is for research use only and is not intended for therapeutic or diagnostic applications. |
| Name | PRC1 {ECO:0000303|PubMed:3028649} |
|---|---|
| Function | Vacuolar serine-type carboxypeptidase involved in degradation of small peptides (PubMed:8679540). Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (PubMed:8679540). Also plays a role in breakdown of the autophagic body and the autophagosome-dependent protein synthesis (PubMed:29514932). Plays a key role in phytochelatin (PC) synthesis from glutathione (GSH) by cleaving the Gly from GSH and form the PC- peptides of the structure (gamma-Glu-Cys)2-Gly (PubMed:17408619). Also involved in resistance to xenobiotics via the degradation of glutathione-S-conjugates (PubMed:19897216). |
| Cellular Location | Vacuole lumen. Note=The vacuolar sorting receptor VPS10 is required for the delivery of ATG42 to the vacuole lumen. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Anti-Carboxypeptidase Y antibody is a participant in degrading small peptides. Carboxypeptidase Y preferentially digests peptides containing aliphatic or hydrophobic residue in P1’ position, as well as methionine, leucine, or phenylalanine in P1 position of ester substrate. A member of the peptidase S10 family, Anti-Carboxypeptidase Y is ideal for researchers interested in Metabolism, Signal Transduction, and Cell Biology research.
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$ 480.00
Cat# ASR4539
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