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AKR1B10 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant AKR1B10.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | O60218 |
| Other Accession | NM_020299 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2B3 |
| Calculated MW | 36020 Da |
| Gene ID | 57016 |
|---|---|
| Other Names | Aldo-keto reductase family 1 member B10, 111-, ARL-1, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase, AKR1B10, AKR1B11 |
| Target/Specificity | AKR1B10 (NP_064695, 76 a.a. ~ 143 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | AKR1B10 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
References
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.[Downregulation of AKR1B10 gene expression in colorectal cancer] Kropotova ES, et al. Mol Biol (Mosk), 2010 Mar-Apr. PMID 20586184.Identification and expression analysis of the aldo-ketoreductase1-B10 gene in primary malignant liver tumours. Heringlake S, et al. J Hepatol, 2010 Feb. PMID 20036025.Novel role for aldose reductase in mediating acute inflammatory responses in the lung. Ravindranath TM, et al. J Immunol, 2009 Dec 15. PMID 20007578.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
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