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ASPA Antibody (monoclonal) (M09)
Mouse monoclonal antibody raised against a partial recombinant ASPA.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P45381 |
| Other Accession | NM_000049 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 3C11 |
| Calculated MW | 35735 Da |
| Gene ID | 443 |
|---|---|
| Other Names | Aspartoacylase, Aminoacylase-2, ACY-2, ASPA, ACY2, ASP |
| Target/Specificity | ASPA (NP_000040, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ASPA Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene.
References
Human variation in alcohol response is influenced by variation in neuronal signaling genes. Joslyn G, et al. Alcohol Clin Exp Res, 2010 May. PMID 20201926.Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue. Le Coq J, et al. Biochemistry, 2008 Mar 18. PMID 18293939.Carrier frequency of autosomal-recessive disorders in the Ashkenazi Jewish population: should the rationale for mutation choice for screening be reevaluated? Fares F, et al. Prenat Diagn, 2008 Mar. PMID 18264947.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Mutational analysis of aspartoacylase: implications for Canavan disease. Hershfield JR, et al. Brain Res, 2007 May 7. PMID 17391648.
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