B2M Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant B2M.
|Application ||WB, IHC, IF, E|
|Calculated MW||13715 Da|
|Other Names||Beta-2-microglobulin, Beta-2-microglobulin form pI 53, B2M|
|Target/Specificity||B2M (AAH32589, 1 a.a. ~ 119 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||B2M Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
1.MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration.Cebrian C, Zucca FA, Mauri P, Steinbeck JA, Studer L, Scherzer CR, Kanter E, Budhu S, Mandelbaum J, Vonsattel JP, Zecca L, Loike JD, Sulzer DNat Commun. 2014 Apr 16;5:3633. doi: 10.1038/ncomms4633.
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