C20orf31 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant C20orf31.
|Application ||WB, IHC, IP, E|
|Calculated MW||64753 Da|
|Other Names||ER degradation-enhancing alpha-mannosidase-like protein 2, EDEM2, C20orf31, C20orf49|
|Target/Specificity||C20orf31 (NP_060687, 479 a.a. ~ 578 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||C20orf31 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).
Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study. Tang W, et al. Blood, 2010 Aug 27. PMID 20802025.A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation. Olivari S, et al. J Biol Chem, 2005 Jan 28. PMID 15579471.Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. Mast SW, et al. Glycobiology, 2005 Apr. PMID 15537790.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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