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CAPG Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a partial recombinant CAPG.

     
  • IF - CAPG Antibody (monoclonal) (M02) AT1388a
    Immunofluorescence of monoclonal antibody to CAPG on HeLa cell. [antibody concentration 30 ug/ml]
    detail
  • WB - CAPG Antibody (monoclonal) (M02) AT1388a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
    detail
  • WB - CAPG Antibody (monoclonal) (M02) AT1388a
    CAPG monoclonal antibody (M02), clone 6D6 Western Blot analysis of CAPG expression in Hela S3 NE ( (Cat # AT1388a )
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF
Primary Accession P40121
Other Accession NM_001747
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 6D6
Calculated MW 38499 Da
Additional Information
Gene ID 822
Other Names Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP
Target/Specificity CAPG (NP_001738, 249 a.a. ~ 348 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsCAPG Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed, but have not been fully described.

References

Proteomic study of macrophages exposed to oxLDL identifies a CAPG polymorphism associated with carotid atherosclerosis. Burillo E, et al. Atherosclerosis, 2009 Nov. PMID 19439302.Proteomic analysis of the stroma-related proteins in nasopharyngeal carcinoma and normal nasopharyngeal epithelial tissues. Li MX, et al. Med Oncol, 2010 Mar. PMID 19242827.Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia. Zhang R, et al. Am J Respir Cell Mol Biol, 2009 Oct. PMID 19188659.The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle. Hubert T, et al. Biochem Biophys Res Commun, 2009 Feb 27. PMID 19166812.Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin. Chen M, et al. J Biol Chem, 2009 Jan 16. PMID 19011242.

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$ 350.00
Cat# AT1388a
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