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CD99 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CD99.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P14209 |
| Other Accession | BC003147 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3A10 |
| Calculated MW | 18848 Da |
| Gene ID | 4267 |
|---|---|
| Other Names | CD99 antigen, E2 antigen, Protein MIC2, T-cell surface glycoprotein E2, CD99, CD99, MIC2, MIC2X, MIC2Y |
| Target/Specificity | CD99 (AAH03147, 23 a.a. ~ 122 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CD99 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Two transcript variants encoding different isoforms have been found for this gene.
References
Stabilization of an E3 ligase-E2-ubiquitin complex increases cell surface MHC class I expression. Duncan LM, et al. J Immunol, 2010 Jun 15. PMID 20483773.Death induction by CD99 ligation in TEL/AML1-positive acute lymphoblastic leukemia and normal B cell precursors. Husak Z, et al. J Leukoc Biol, 2010 Aug. PMID 20453109.CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis. Rocchi A, et al. J Clin Invest, 2010 Mar 1. PMID 20197622.Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. Yoshino N, et al. Ann Thorac Cardiovasc Surg, 2009 Oct. PMID 19901887.Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis. Burkhardt J, et al. J Rheumatol, 2009 Oct. PMID 19723899.
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