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CER1 Antibody (monoclonal) (M12)
Mouse monoclonal antibody raised against a full length recombinant CER1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O95813 |
| Other Accession | NM_005454 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4D5 |
| Calculated MW | 30084 Da |
| Gene ID | 9350 |
|---|---|
| Other Names | Cerberus, Cerberus-related protein, DAN domain family member 4, CER1, DAND4 |
| Target/Specificity | CER1 (NP_005445.1, 158 a.a. ~ 266 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CER1 Antibody (monoclonal) (M12) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity.
References
A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. Young RP, et al. Postgrad Med J, 2009 Oct. PMID 19789190.High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Yerges LM, et al. J Bone Miner Res, 2009 Dec. PMID 19453261.Lung cancer susceptibility model based on age, family history and genetic variants. Young RP, et al. PLoS One, 2009. PMID 19390575.Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women. Tang PL, et al. J Bone Miner Res, 2009 Jun. PMID 19113921.Clinical and cytogenetic characterization of 13 Dutch patients with deletion 9p syndrome: Delineation of the critical region for a consensus phenotype. Swinkels ME, et al. Am J Med Genet A, 2008 Jun 1. PMID 18452192.
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