CMTM5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CKLFSF5.
|Application ||WB, E|
|Calculated MW||24653 Da|
|Other Names||CKLF-like MARVEL transmembrane domain-containing protein 5, Chemokine-like factor superfamily member 5, CMTM5, CKLFSF5|
|Target/Specificity||CKLFSF5 (AAH13109, 1 a.a. ~ 156 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CMTM5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene belongs to the chemokine-like factor gene superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
CMTM5-v1, a four-transmembrane protein, presents a secreted form released via a vesicle-mediated secretory pathway. Li H, et al. BMB Rep, 2010 Mar. PMID 20356458.CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha. Guo X, et al. Biochem Biophys Res Commun, 2009 Sep 11. PMID 19577543.CMTM5-v1 induces apoptosis in cervical carcinoma cells. Shao L, et al. Biochem Biophys Res Commun, 2009 Feb 20. PMID 19124004.CMTM5 exhibits tumor suppressor activities and is frequently silenced by methylation in carcinoma cell lines. Shao L, et al. Clin Cancer Res, 2007 Oct 1. PMID 17908965.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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