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CORO1A Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant CORO1A.

     
  • WB - CORO1A Antibody (monoclonal) (M01) AT1594a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.96 KDa) .
    detail
  • WB - CORO1A Antibody (monoclonal) (M01) AT1594a
    CORO1A monoclonal antibody (M01), clone 4G10 Western Blot analysis of CORO1A expression in K-562 ( (Cat # AT1594a )
    detail
  • IHC - CORO1A Antibody (monoclonal) (M01) AT1594a
    Immunoperoxidase of monoclonal antibody to CORO1A on formalin-fixed paraffin-embedded human lung. [antibody concentration 3 ug/ml]
    detail
  • E - CORO1A Antibody (monoclonal) (M01) AT1594a
    Detection limit for recombinant GST tagged CORO1A is approximately 0.1ng/ml as a capture antibody.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession P31146
Other Accession NM_007074
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 4G10
Calculated MW 51026 Da
Additional Information
Gene ID 11151
Other Names Coronin-1A, Coronin-like protein A, Clipin-A, Coronin-like protein p57, Tryptophan aspartate-containing coat protein, TACO, CORO1A, CORO1
Target/Specificity CORO1A (NP_009005, 360 a.a. ~ 461 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsCORO1A Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16.

References

1.Coronin 1 regulates cognition and behavior through modulation of cAMP/protein kinase A signaling.Jayachandran R, Liu X, Bosedasgupta S, Muller P, Zhang CL, Moshous D, Studer V, Schneider J, Genoud C, Fossoud C, Gambino F, Khelfaoui M, Muller C, Bartholdi D, Rossez H, Stiess M, Houbaert X, Jaussi R, Frey D, Kammerer RA, Deupi X, de Villartay JP, Luthi A, Humeau Y, Pieters JPLoS Biol. 2014 Mar 25;12(3):e1001820. doi: 10.1371/journal.pbio.1001820. eCollection 2014 Mar.2.The actin-binding protein CORO1A is a novel PU.1 (SPI1)- and CEBPA-regulated gene with significantly lower expression in APL and CEBPA-mutated AML patients.Federzoni EA, Humbert M, Valk PJ, Behre G, Leibundgut EO, Torbett BE, Fey MF, Tschan MP.Br J Haematol. 2012 Dec 17. doi: 10.1111/bjh.12170.3.Coronin-1 Is Associated with Neutrophil Survival and Is Cleaved during Apoptosis: Potential Implication in Neutrophils from Cystic Fibrosis Patients.Moriceau S, Kantari C, Mocek J, Davezac N, Gabillet J, Guerrera IC, Brouillard F, Tondelier D, Sermet-Gaudelus I, Danel C, Lenoir G, Daniel S, Edelman A, Witko-Sarsat V.J Immunol. 2009 Jun 1;182(11):7254-63.

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$ 350.00
Cat# AT1594a
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Availability: 7-10 days
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