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CTNNBIP1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CTNNBIP1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NSA3 |
| Other Accession | NM_020248 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 5C6 |
| Calculated MW | 9170 Da |
| Gene ID | 56998 |
|---|---|
| Other Names | Beta-catenin-interacting protein 1, Inhibitor of beta-catenin and Tcf-4, CTNNBIP1, ICAT |
| Target/Specificity | CTNNBIP1 (NP_064633, 1 a.a. ~ 81 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CTNNBIP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene.
References
Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs. Alves Pereira KM, et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2010 Mar. PMID 20219600.Reduced beta-catenin expression is associated with good prognosis in Astrocytoma. Zhang LY, et al. Pathol Oncol Res, 2010 Jun. PMID 20182836.ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657. Wang W, et al. Cell Biochem Funct, 2009 Aug. PMID 19569129.Comparative proteomics analysis on differentiation of human promyelocytic leukemia HL-60 cells into granulocyte and monocyte lineages. Wang WJ, et al. Ai Zheng, 2009 Feb. PMID 19550115.HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells. Wang L, et al. Int J Cancer, 2009 Apr 1. PMID 19089909.
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