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DCN Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant DCN.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P07585 |
| Other Accession | BC005322 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 3H4-1F4 |
| Calculated MW | 39747 Da |
| Gene ID | 1634 |
|---|---|
| Other Names | Decorin, Bone proteoglycan II, PG-S2, PG40, DCN, SLRR1B |
| Target/Specificity | DCN (AAH05322, 1 a.a. ~ 359 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DCN Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome.
References
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Decorin expression is decreased in human idiopathic fetal growth restriction. Swan BC, et al. Reprod Fertil Dev, 2010. PMID 20591329.Decorin transfection suppresses profibrogenic genes and myofibroblast formation in human corneal fibroblasts. Mohan RR, et al. Exp Eye Res, 2010 Aug. PMID 20546727.Candidate gene study to investigate the genetic determinants of normal variation in central corneal thickness. Dimasi DP, et al. Mol Vis, 2010 Mar 31. PMID 20360993.
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