DLX3 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a full length recombinant DLX3.
|Application ||WB, E|
|Calculated MW||31738 Da|
|Other Names||Homeobox protein DLX-3, DLX3|
|Target/Specificity||DLX3 (AAH12361, 1 a.a. ~ 287 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||DLX3 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism.
Uncombable hair and atopic dermatitis in a case of trichodento-osseous syndrome. Mayer DE, et al. J Dtsch Dermatol Ges, 2010 Feb. PMID 20151948.Thickness and microhardness of deciduous tooth enamel with known DLX3 mutation. Hyun HK, et al. Arch Oral Biol, 2009 Sep. PMID 19608154.High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Yerges LM, et al. J Bone Miner Res, 2009 Dec. PMID 19453261.Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation. Di Costanzo A, et al. Cell Cycle, 2009 Apr 15. PMID 19282665.Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. Vieira AR, et al. Genet Med, 2008 Sep. PMID 18978678.
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