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DMRT1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant DMRT1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y5R6 |
| Other Accession | BC040847 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1G11 |
| Calculated MW | 39473 Da |
| Gene ID | 1761 |
|---|---|
| Other Names | Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1, DMRT1, DMT1 |
| Target/Specificity | DMRT1 (AAH40847.1, 1 a.a. ~ 373 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DMRT1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.
References
Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. Turnbull C, et al. Nat Genet, 2010 Jul. PMID 20543847.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. Krentz AD, et al. Proc Natl Acad Sci U S A, 2009 Dec 29. PMID 20007774.Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis. Cheng HH, et al. Cell Res, 2006 Apr. PMID 16617334.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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