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FMR1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant FMR1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q06787 |
| Other Accession | NM_002024 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2D4 |
| Calculated MW | 71174 Da |
| Gene ID | 2332 |
|---|---|
| Other Names | Fragile X mental retardation protein 1, FMRP, Protein FMR-1, FMR1 |
| Target/Specificity | FMR1 (NP_002015, 121 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FMR1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
References
An information-rich CGG repeat primed PCR that detects the full range of fragile X expanded alleles and minimizes the need for southern blot analysis. Chen L, et al. J Mol Diagn, 2010 Sep. PMID 20616364.Genetic diversity of the fragile X syndrome gene (FMR1) in a large Sub-Saharan West African population. Peprah EK, et al. Ann Hum Genet, 2010 Jul. PMID 20597902.An fMRI study of the prefrontal activity during the performance of a working memory task in premutation carriers of the fragile X mental retardation 1 gene with and without fragile X-associated tremor/ataxia syndrome (FXTAS). Hashimoto RI, et al. J Psychiatr Res, 2010 May 26. PMID 20537351.hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Lee EK, et al. Nat Struct Mol Biol, 2010 Jun. PMID 20473314.A simple, high-throughput assay for Fragile X expanded alleles using triple repeat primed PCR and capillary electrophoresis. Lyon E, et al. J Mol Diagn, 2010 Jul. PMID 20431035.
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