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FOXO1A Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a partial recombinant FOXO1A.

     
  • IF - FOXO1A Antibody (monoclonal) (M02) AT2099a
    Immunofluorescence of monoclonal antibody to FOXO1 on HeLa cell . [antibody concentration 10 ug/ml]
    detail
  • WB - FOXO1A Antibody (monoclonal) (M02) AT2099a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
    detail
  • E - FOXO1A Antibody (monoclonal) (M02) AT2099a
    Detection limit for recombinant GST tagged FOXO1A is approximately 1ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, E
Primary Accession Q12778
Other Accession NM_002015
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 1F11
Calculated MW 69662 Da
Additional Information
Gene ID 2308
Other Names Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, FOXO1, FKHR, FOXO1A
Target/Specificity FOXO1A (NP_002006, 556 a.a. ~ 655 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsFOXO1A Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.

References

COMMON VARIANTS IN 40 GENES ASSESSED FOR DIABETES INCIDENCE AND RESPONSE TO METFORMIN AND LIFESTYLE INTERVENTIONS IN THE DIABETES PREVENTION PROGRAM. Jablonski KA, et al. Diabetes, 2010 Aug 3. PMID 20682687.Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Zhao Y, et al. Nat Cell Biol, 2010 Jul. PMID 20543840.FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. Chen CC, et al. Dev Cell, 2010 Apr 20. PMID 20412774.Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression. Banerjee A, et al. J Virol, 2010 Jun. PMID 20357092.Advanced glycation end-products affect transcription factors regulating insulin gene expression. Puddu A, et al. Biochem Biophys Res Commun, 2010 Apr 23. PMID 20353756.

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$ 350.00
Cat# AT2099a
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