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FRG1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant FRG1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IP |
|---|---|
| Primary Accession | Q14331 |
| Other Accession | BC053997 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4A5 |
| Calculated MW | 29172 Da |
| Gene ID | 2483 |
|---|---|
| Other Names | Protein FRG1, FSHD region gene 1 protein, FRG1 |
| Target/Specificity | FRG1 (AAH53997, 1 a.a. ~ 258 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FRG1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene maps to a location 100 kb centromeric of the repeat units on chromosome 4q35 which are deleted in facioscapulohumeral muscular dystrophy (FSHD). It is evolutionarily conserved and has related sequences on multiple human chromosomes but DNA sequence analysis did not reveal any homology to known genes. In vivo studies demonstrate the encoded protein is localized to the nucleolus.
References
1.RNA Interference Improves Myopathic Phenotypes in Mice Over-expressing FSHD Region Gene 1 (FRG1).Wallace LM, Garwick-Coppens SE, Tupler R, Harper SQ.Mol Ther. 2011 Jul 5. doi: 10.1038/mt.2011.118. [Epub ahead of print]
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