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FUCA1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant FUCA1.
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P04066 |
| Other Accession | BC017338 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 1D4 |
| Calculated MW | 53689 Da |
| Gene ID | 2517 |
|---|---|
| Other Names | Tissue alpha-L-fucosidase, Alpha-L-fucosidase I, Alpha-L-fucoside fucohydrolase 1, Alpha-L-fucosidase 1, FUCA1 |
| Target/Specificity | FUCA1 (AAH17338, 23 a.a. ~ 461 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FUCA1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.
References
Spectrofluorimetric method for measuring the activity of the enzyme alpha-L-fucosidase using the ion associate of 2-chloro-4-nitro phenol-rhodamine-B. El-Shahawi MS, et al. Talanta, 2009 Nov 15. PMID 19782187. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. Palmieri RT, et al. Cancer Epidemiol Biomarkers Prev, 2008 Dec. PMID 19064572. Activity of lysosomal exoglycosidases in saliva of patients with HIV infection. Kna? M, et al. Adv Med Sci, 2007. PMID 18217416. Crypticity and functional distribution of the membrane associated alpha-L-fucosidase of human sperm. Venditti JJ, et al. Mol Reprod Dev, 2007 Jun. PMID 17133604.
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