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FZD3 Antibody (monoclonal) (M09)
Mouse monoclonal antibody raised against a partial recombinant FZD3.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q9NPG1 |
| Other Accession | NM_017412 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2H5 |
| Calculated MW | 76263 Da |
| Gene ID | 7976 |
|---|---|
| Other Names | Frizzled-3, Fz-3, hFz3, FZD3 |
| Target/Specificity | FZD3 (NP_059108, 55 a.a. ~ 157 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FZD3 Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development.
References
Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. Inkster B, et al. Neuroimage, 2010 Nov 15. PMID 20219685.Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer. Kawano Y, et al. Br J Cancer, 2009 Apr 7. PMID 19277043.Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. Greg?rio SP, et al. Psychiatry Res, 2009 Jan 30. PMID 19054571.Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Wang HX, et al. Mol Hum Reprod, 2009 Jan. PMID 19038973.The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population. Kishimoto M, et al. Behav Brain Funct, 2008 Aug 15. PMID 18702828.
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