GABPA Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant GABPA.
|Application ||WB, IHC, IF|
|Calculated MW||51295 Da|
|Other Names||GA-binding protein alpha chain, GABP subunit alpha, Nuclear respiratory factor 2 subunit alpha, Transcription factor E4TF1-60, GABPA, E4TF1A|
|Target/Specificity||GABPA (NP_002031, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GABPA Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype.
C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements. Levy S, et al. IUBMB Life, 2010 Mar. PMID 20232342.Interaction between SNPs in the NRF2 gene and elite endurance performance. Eynon N, et al. Physiol Genomics, 2010 Mar 3. PMID 20028934.Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin. Kim YR, et al. J Pathol, 2010 Mar. PMID 19967722.Nuclear respiratory factor 2 induces the expression of many but not all human proteins acting in mitochondrial DNA transcription and replication. Bruni F, et al. J Biol Chem, 2010 Feb 5. PMID 19951946.Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery. Boros J, et al. Genome Res, 2009 Nov. PMID 19687146.
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