GCA Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full-length recombinant GCA.
|Application ||WB, IF, E|
|Calculated MW||24010 Da|
|Other Names||Grancalcin, GCA, GCL|
|Target/Specificity||GCA (AAH05214, 1 a.a. ~ 217 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GCA Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients. Couturier N, et al. Eur J Hum Genet, 2009 Jun. PMID 19156166.IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk. Mart?nez A, et al. Eur J Hum Genet, 2008 Jul. PMID 18285833.The association between the IFIH1 locus and type 1 diabetes. Qu HQ, et al. Diabetologia, 2008 Mar. PMID 18071670.A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569.
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