GPNMB Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant GPNMB.
|Application ||WB, E|
|Calculated MW||63923 Da|
|Other Names||Transmembrane glycoprotein NMB, Transmembrane glycoprotein HGFIN, GPNMB, HGFIN, NMB|
|Target/Specificity||GPNMB (NP_001005340, 104 a.a. ~ 203 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GPNMB Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
1.GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity.Fiorentini C, Bodei S, Bedussi F, Fragni M, Bonini SA, Simeone C, Zani D, Berruti A, Missale C, Memo M, Spano P, Sigala SExp Cell Res. 2014 Feb 28. pii: S0014-4827(14)00088-3. doi: 10.1016/j.yexcr.2014.02.025.2.Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension.Kompass KS, Agapova OA, Li W, Kaufman PL, Rasmussen CA, Hernandez MR.BMC Neurosci. 2008 Sep 26;9:93.
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