GRHPR Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant GRHPR.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9UBQ7 |
Other Accession | BC000605 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG1 Kappa |
Clone Names | 4E6-1F2 |
Calculated MW | 35668 Da |
Gene ID | 9380 |
---|---|
Other Names | Glyoxylate reductase/hydroxypyruvate reductase, GRHPR, GLXR |
Target/Specificity | GRHPR (AAH00605, 1 a.a. ~ 328 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Dilution | WB~~1:500~1000 |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | GRHPR Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.
References
Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling. Levin-Iaina N, et al. J Urol, 2009 May. PMID 19296982.A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2. Takayama T, et al. Nephrol Dial Transplant, 2007 Aug. PMID 17510093.Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase. Booth MP, et al. J Mol Biol, 2006 Jun 30. PMID 16756993.The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901.Primary hyperoxaluria: from gene defects to designer drugs? Danpure CJ. Nephrol Dial Transplant, 2005 Aug. PMID 15956068.
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