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GSTA1 Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a full-length recombinant GSTA1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P08263 |
| Other Accession | BC053578.1 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1F9 |
| Calculated MW | 25631 Da |
| Gene ID | 2938 |
|---|---|
| Other Names | Glutathione S-transferase A1, GST HA subunit 1, GST class-alpha member 1, GST-epsilon, GSTA1-1, GTH1, Glutathione S-transferase A1, N-terminally processed, GSTA1 |
| Target/Specificity | GSTA1 (AAH53578.1, 1 a.a. ~ 222 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | GSTA1 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.
References
Influence of glutathione S-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation. Elhasid R, et al. Pediatr Blood Cancer, 2010 Jul 29. PMID 20672371.The expression of GST isoenzymes and p53 in non-small cell lung cancer. Oguzt?zun S, et al. Folia Histochem Cytobiol, 2010 Jan 1. PMID 20529827.The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. Hawken SJ, et al. Hum Genet, 2010 Jul. PMID 20437058.Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort. Eriksen KT, et al. J Toxicol Environ Health A, 2010 Jan. PMID 20391138.Genetic polymorphisms in GSTA1, GSTP1, GSTT1, and GSTM1 and gastric cancer risk in a Vietnamese population. Nguyen TV, et al. Oncol Res, 2010. PMID 20377137.
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