GTF2I Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant GTF2I.
|Application ||WB, IF, E|
|Calculated MW||112416 Da|
|Other Names||General transcription factor II-I, GTFII-I, TFII-I, Bruton tyrosine kinase-associated protein 135, BAP-135, BTK-associated protein 135, SRF-Phox1-interacting protein, SPIN, Williams-Beuren syndrome chromosomal region 6 protein, GTF2I, BAP135, WBSCR6|
|Target/Specificity||GTF2I (AAH04472.1, 36 a.a. ~ 274 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GTF2I Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7, 13 and 21.
Partial 7q11.23 deletions further implicate GTF2I and GTF2IRD1 as the main genes responsible for the Williams-Beuren syndrome neurocognitive profile. Antonell A, et al. J Med Genet, 2010 May. PMID 19897463.Williams-Beuren syndrome-associated transcription factor TFII-I regulates osteogenic marker genes. Lazebnik MB, et al. J Biol Chem, 2009 Dec 25. PMID 19880526.Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells. Sacrist?n C, et al. Eur J Immunol, 2009 Sep. PMID 19701889.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.Phase specific functions of the transcription factor TFII-I during cell cycle. Ashworth T, et al. Cell Cycle, 2009 Feb 15. PMID 19182516.
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