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HDAC8 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant HDAC8.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q9BY41 |
| Other Accession | BC050433 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2F4 |
| Calculated MW | 41758 Da |
| Gene ID | 55869 |
|---|---|
| Other Names | Histone deacetylase 8, HD8, HDAC8, HDACL1 |
| Target/Specificity | HDAC8 (AAH50433, 1 a.a. ~ 377 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | HDAC8 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function . Dowling DP, et al. Biochemistry, 2010 Jun 22. PMID 20545365.Activation and inhibition of histone deacetylase 8 by monovalent cations. Gantt SL, et al. J Biol Chem, 2010 Feb 26. PMID 20029090.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.Novel structural insights into class I and II histone deacetylases. Ficner R. Curr Top Med Chem, 2009. PMID 19355988.
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