HELZ Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant HELZ.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, IF, E |
---|---|
Primary Accession | P42694 |
Other Accession | NM_014877 |
Reactivity | Human |
Host | mouse |
Clonality | Monoclonal |
Isotype | IgG2b Kappa |
Clone Names | 5B2 |
Calculated MW | 218970 Da |
Gene ID | 9931 |
---|---|
Other Names | Probable helicase with zinc finger domain, 364-, Down-regulated in human cancers protein, HELZ, DRHC, KIAA0054 |
Target/Specificity | HELZ (NP_055692, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Dilution | WB~~1:500~1000 |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | HELZ Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).
References
1.The Putative RNA Helicase HELZ Promotes Cell Proliferation, Translation Initiation and Ribosomal Protein S6 Phosphorylation.Hasgall PA, Hoogewijs D, Faza MB, Panse VG, Wenger RH, Camenisch G.PLoS One. 2011;6(7):e22107. Epub 2011 Jul 13.
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