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HERPUD1 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant HERPUD1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IP, E |
|---|---|
| Primary Accession | Q15011 |
| Other Accession | NM_014685 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2G7 |
| Calculated MW | 43720 Da |
| Gene ID | 9709 |
|---|---|
| Other Names | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein, Methyl methanesulfonate (MMF)-inducible fragment protein 1, HERPUD1, HERP, KIAA0025, MIF1 |
| Target/Specificity | HERPUD1 (NP_055500, 74 a.a. ~ 180 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | HERPUD1 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.
References
1.BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis.Wang Y, Wan B, Li D, Zhou J, Li R, Bai M, Chen F, Yu L.Biochem Biophys Res Commun. 2012 Jun 16.2.Decreased ER-associated degradation of ?-TCR induced by Grp78 depletion with the SubAB cytotoxin.Lass A, Kujawa M, McConnell E, Paton AW, Paton JC, Wojcik C.Int J Biochem Cell Biol. 2008;40(12):2865-79. Epub 2008 Jun 20.
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