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HIPK1 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant HIPK1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | Q86Z02 |
| Other Accession | BC028408 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1F2 |
| Calculated MW | 130843 Da |
| Gene ID | 204851 |
|---|---|
| Other Names | Homeodomain-interacting protein kinase 1, Nuclear body-associated kinase 2, HIPK1, KIAA0630, MYAK, NBAK2 |
| Target/Specificity | HIPK1 (AAH28408, 330 a.a. ~ 430 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | HIPK1 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
References
HIPK1 interacts with c-Myb and modulates its activity through phosphorylation. Matre V, et al. Biochem Biophys Res Commun, 2009 Oct 9. PMID 19646965.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. Aikawa Y, et al. EMBO J, 2006 Sep 6. PMID 16917507.Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. Li X, et al. J Biol Chem, 2005 Apr 15. PMID 15701637.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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